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KMID : 1007020050030010035
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Korean Soceity of Osteroporosis
2005 Volume.3 No. 1 p.35 ~ p.45
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The Association between Several Factors Affecting Aortic Calcification and Bone Mineral Density in Postmenopausal Women
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Han Ho
Hong Sang-Mo
Kang Jun-Goo
Lee Chang-Beom
Kim Dong-Sun
Park Yong-Soo
Ahn You-Hern
Kim Tae-Hwa
Choi Woong-Hwan
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Abstract
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Objectives: Aortic calcification increases with age and several epidemiologic studies shows that it is linked to cardiovascular mortalitysuch as myocardial infarction and stroke. Elderly person whose degree of aortic calcification increases greater tends to lose more bone than those whose gain for aortic calcification is minimal. Osteoclastic potential is greater in preosteoclasts from bone marrow in hyperlipidemic compared with normal mice. Therefore we are to evaluate the factors that contributes to vascular calcium accumulation and the association between lipid profile and bone mineral density(BMD).
Methods: Postmenopausal women(more than 50 years of age) who visited the health promotion center at Hanyang Univ. hospital from Jan 2003 to Sep 2005 have taken baseline checkup including history taking, physical examination, and blood sampling. Lumbar spinal and femoral BMD was measured by dual energy X-ray absorptiometry(DXA). The presence of aortic calcification was identified by Abdominal CT. According to the extent of sum of aortic calcification observed in all cross sectional area, all patients were divided to 3 groups: None(No calcification), Mild to moderate(0-180°), Severe(180-360°).
Results: Patients with aortic calcification had significantly lower BMD than those without aortic calcification. High triglyceride and low HDL cholesterol was significantly associated with aortic calcification. Diabetic patients had a higher incidence of aortic calcification than non-diabetic patients(83% vs 49%; P value＜0.01), and they had significantly higher triglyceride and lower HDL cholesterol levels than non-diabetic patients. As the degree of aortic calcification increases, BMD especially femoral BMD tends to decreases. However, none of the lipid profiles was significantly correlated with BMD.
Conclusion: There is a reciprocal relationship between degree of aortic calcification and bone mineral density. Among other cardiovascular risk factors, DM is a potent risk factor for aortic calcification. In addition to metabolic stress induced by hyperglycemia, dyslipidemia may contribute to vascular calcium accumulation. Although dyslipidemia including high TG and low HDL is significantly associated with aortic calcification, there is no meaningful correlation between serum lipid level and BMD.
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KEYWORD
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Aortic Calcification, Bone Mineral Density, Dyslipidemia
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